SSR1-DMD Fusion FISH Probe
The SSR1-DMD Fusion FISH Probe is used to confirm a fusion of the SSR1 and DMD genes. The fusion of the SSR1 and DMD genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SSR1-DMD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-RERE | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-REOR | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-REGO | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-REGR | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-REAQ | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-ORRE | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-OROR | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-ORGO | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-ORAQ | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-GORE | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-GOOR | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-GOGO | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-GOGR | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-GOAQ | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-GRRE | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-GROR | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-GRGO | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-GRGR | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-GRAQ | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-AQRE | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-AQOR | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-AQGO | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-AQGR | 20 (40 μL) | 200 μL |
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| SSR1-DMD-20-AQAQ | 20 (40 μL) | 200 μL |
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DMD Gene Summary
This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016]
Gene Name: Dystrophin
Chromosome: CHRX: 31137344 -33357726
Locus: Xp21.2-p21.1
SSR1 Gene Summary
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Name: Signal Sequence Receptor Subunit 1
Chromosome: CHR6: 7281287 -7313541
Locus: 6p24.3
Gene Diseases
The SSR1 DMD Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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