SSH3-KDM2A Fusion FISH Probe
The SSH3-KDM2A Fusion FISH Probe is used to confirm a fusion of the SSH3 and KDM2A genes. The fusion of the SSH3 and KDM2A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SSH3-KDM2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SSH3-KDM2A-20-AQAQ | 20 (40 μL) | 200 μL |
|
KDM2A Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Lysine Demethylase 2A
Chromosome: CHR11: 66886739 -67025550
Locus: 11q13.2
SSH3 Gene Summary
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
Gene Name: Slingshot Protein Phosphatase 3
Chromosome: CHR11: 67070918 -67080078
Locus: 11q13.2
Gene Diseases
The SSH3 KDM2A Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|