SRP68-RCAN1 Fusion FISH Probe
The SRP68-RCAN1 Fusion FISH Probe is used to confirm a fusion of the SRP68 and RCAN1 genes. The fusion of the SRP68 and RCAN1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SRP68-RCAN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-RERE | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-REOR | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-REGO | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-REGR | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-REAQ | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-ORRE | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-OROR | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-ORGO | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-GORE | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-GOOR | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-GOGO | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-GOGR | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-GRRE | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-GROR | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-GRGO | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-GRGR | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-AQRE | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-AQOR | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-AQGO | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-AQGR | 20 (40 μL) | 200 μL |
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| SRP68-RCAN1-20-AQAQ | 20 (40 μL) | 200 μL |
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RCAN1 Gene Summary
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: Regulator Of Calcineurin 1
Chromosome: CHR21: 35888783 -35987382
Locus: 21q22.12
SRP68 Gene Summary
This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
Gene Name: Signal Recognition Particle 68
Chromosome: CHR17: 74035190 -74068607
Locus: 17q25.1
Gene Diseases
The SRP68 RCAN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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