SPTLC1-IARS Fusion FISH Probe
The SPTLC1-IARS Fusion FISH Probe is used to confirm a fusion of the SPTLC1 and IARS genes. The fusion of the SPTLC1 and IARS genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPTLC1-IARS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-RERE | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-REOR | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-REGO | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-REGR | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-REAQ | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-ORRE | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-OROR | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-ORGO | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-GORE | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-GOOR | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-GOGO | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-GOGR | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-GRRE | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-GROR | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-GRGO | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-GRGR | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-AQRE | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-AQOR | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-AQGO | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-AQGR | 20 (40 μL) | 200 μL |
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| SPTLC1-IARS-20-AQAQ | 20 (40 μL) | 200 μL |
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IARS Gene Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]
Gene Name: Isoleucyl-tRNA Synthetase
Chromosome: CHR9: 94972624 -95056038
Locus: 9q22.31
SPTLC1 Gene Summary
This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013]
Gene Name: Serine Palmitoyltransferase Long Chain Base Subunit 1
Chromosome: CHR9: 94793426 -94877690
Locus: 9q22.31
Gene Diseases
The SPTLC1 IARS Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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