SPTBN2-PC Fusion FISH Probe
The SPTBN2-PC Fusion FISH Probe is used to confirm a fusion of the SPTBN2 and PC genes. The fusion of the SPTBN2 and PC genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPTBN2-PC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-RERE | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-REOR | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-REGO | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-REGR | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-REAQ | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-ORRE | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-OROR | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-ORGO | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-GORE | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-GOOR | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-GOGO | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-GOGR | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-GRRE | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-GROR | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-GRGO | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-GRGR | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-AQRE | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-AQOR | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-AQGO | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-AQGR | 20 (40 μL) | 200 μL |
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| SPTBN2-PC-20-AQAQ | 20 (40 μL) | 200 μL |
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PC Gene Summary
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Pyruvate Carboxylase
Chromosome: CHR11: 66615996 -66725847
Locus: 11q13.2
SPTBN2 Gene Summary
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
Gene Name: Spectrin Beta, Non-erythrocytic 2
Chromosome: CHR11: 66452719 -66488870
Locus: 11q13.2
Gene Diseases
The SPTBN2 PC Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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