SPTAN1-AUH Fusion FISH Probe
The SPTAN1-AUH Fusion FISH Probe is used to confirm a fusion of the SPTAN1 and AUH genes. The fusion of the SPTAN1 and AUH genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPTAN1-AUH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-RERE | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-REOR | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-REGO | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-REGR | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-REAQ | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-ORRE | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-OROR | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-ORGO | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-GORE | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-GOOR | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-GOGO | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-GOGR | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-GRRE | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-GROR | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-GRGO | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-GRGR | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-AQRE | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-AQOR | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-AQGO | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-AQGR | 20 (40 μL) | 200 μL |
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| SPTAN1-AUH-20-AQAQ | 20 (40 μL) | 200 μL |
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AUH Gene Summary
This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Name: AU RNA Binding Methylglutaconyl-CoA Hydratase
Chromosome: CHR9: 93976096 -94124206
Locus: 9q22.31
SPTAN1 Gene Summary
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Gene Name: Spectrin Alpha, Non-erythrocytic 1
Chromosome: CHR9: 131314836 -131395944
Locus: 9q34.11
Gene Diseases
The SPTAN1 AUH Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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