SPOP-TAC4 Fusion FISH Probe
The SPOP-TAC4 Fusion FISH Probe is used to confirm a fusion of the SPOP and TAC4 genes. The fusion of the SPOP and TAC4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPOP-TAC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-RERE | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-REOR | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-REGO | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-REGR | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-REAQ | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-ORRE | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-OROR | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-ORGO | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-GORE | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-GOOR | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-GOGO | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-GOGR | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-GRRE | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-GROR | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-GRGO | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-GRGR | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-AQRE | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-AQOR | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-AQGO | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-AQGR | 20 (40 μL) | 200 μL |
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| SPOP-TAC4-20-AQAQ | 20 (40 μL) | 200 μL |
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SPOP Gene Summary
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Speckle Type BTB/POZ Protein
Chromosome: CHR17: 47676245 -47755525
Locus: 17q21.33
TAC4 Gene Summary
This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Tachykinin 4 (hemokinin)
Chromosome: CHR17: 47915670 -47925379
Locus: 17q21.33
Gene Diseases
The SPOP TAC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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