SPOCK2-ASCC1 Fusion FISH Probe
The SPOCK2-ASCC1 Fusion FISH Probe is used to confirm a fusion of the SPOCK2 and ASCC1 genes. The fusion of the SPOCK2 and ASCC1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPOCK2-ASCC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-RERE | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-REOR | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-REGO | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-REGR | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-REAQ | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-ORRE | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-OROR | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-ORGO | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-GORE | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-GOOR | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-GOGO | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-GOGR | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-GRRE | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-GROR | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-GRGO | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-GRGR | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-AQRE | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-AQOR | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-AQGO | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-AQGR | 20 (40 μL) | 200 μL |
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| SPOCK2-ASCC1-20-AQAQ | 20 (40 μL) | 200 μL |
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SPOCK2 Gene Summary
This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: SPARC/osteonectin, Cwcv And Kazal Like Domains Proteoglycan 2
Chromosome: CHR10: 73818791 -73848790
Locus: 10q22.1
ASCC1 Gene Summary
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Activating Signal Cointegrator 1 Complex Subunit 1
Chromosome: CHR10: 73856273 -73976183
Locus: 10q22.1
Gene Diseases
The SPOCK2 ASCC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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