SPO11-GSTA1 Fusion FISH Probe
The SPO11-GSTA1 Fusion FISH Probe is used to confirm a fusion of the SPO11 and GSTA1 genes. The fusion of the SPO11 and GSTA1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPO11-GSTA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-RERE | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-REOR | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-REGO | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-REGR | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-REAQ | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-ORRE | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-OROR | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-ORGO | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-GORE | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-GOOR | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-GOGO | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-GOGR | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-GRRE | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-GROR | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-GRGO | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-GRGR | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-AQRE | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-AQOR | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-AQGO | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-AQGR | 20 (40 μL) | 200 μL |
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| SPO11-GSTA1-20-AQAQ | 20 (40 μL) | 200 μL |
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GSTA1 Gene Summary
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Glutathione S-transferase Alpha 1
Chromosome: CHR6: 52656177 -52668664
Locus: 6p12.2
SPO11 Gene Summary
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
Gene Name: SPO11, Initiator Of Meiotic Double Stranded Breaks
Chromosome: CHR20: 55904830 -55919049
Locus: 20q13.31
Gene Diseases
The SPO11 GSTA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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