SPINK5-DNAJC21 Fusion FISH Probe
The SPINK5-DNAJC21 Fusion FISH Probe is used to confirm a fusion of the SPINK5 and DNAJC21 genes. The fusion of the SPINK5 and DNAJC21 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPINK5-DNAJC21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-RERE | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-REOR | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-REGO | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-REGR | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-REAQ | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-ORRE | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-OROR | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-ORGO | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-GORE | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-GOOR | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-GOGO | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-GOGR | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-GRRE | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-GROR | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-GRGO | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-GRGR | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-AQRE | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-AQOR | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-AQGO | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-AQGR | 20 (40 μL) | 200 μL |
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| SPINK5-DNAJC21-20-AQAQ | 20 (40 μL) | 200 μL |
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SPINK5 Gene Summary
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Serine Peptidase Inhibitor, Kazal Type 5
Chromosome: CHR5: 147443534 -147516925
Locus: 5q32
DNAJC21 Gene Summary
This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the precursor 45S ribosomal RNA and may be involved in early nuclear ribosomal RNA biogenesis and maturation of the 60S ribosomal subunit. Mutations in this gene result in Bone marrow failure syndrome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2017]
Gene Name: DnaJ Heat Shock Protein Family (Hsp40) Member C21
Chromosome: CHR5: 34929697 -34959069
Locus: 5p13.2
Gene Diseases
The SPINK5 DNAJC21 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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