SPEN-TNFRSF1B Fusion FISH Probe
The SPEN-TNFRSF1B Fusion FISH Probe is used to confirm a fusion of the SPEN and TNFRSF1B genes. The fusion of the SPEN and TNFRSF1B genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPEN-TNFRSF1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-RERE | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-REOR | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-REGO | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-REGR | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-REAQ | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-ORRE | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-OROR | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-ORGO | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-GORE | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-GOOR | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-GOGO | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-GOGR | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-GRRE | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-GROR | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-GRGO | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-GRGR | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-AQRE | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-AQOR | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-AQGO | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-AQGR | 20 (40 μL) | 200 μL |
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| SPEN-TNFRSF1B-20-AQAQ | 20 (40 μL) | 200 μL |
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TNFRSF1B Gene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Gene Name: TNF Receptor Superfamily Member 1B
Chromosome: CHR1: 12227059 -12269277
Locus: 1p36.22
SPEN Gene Summary
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
Gene Name: Spen Family Transcriptional Repressor
Chromosome: CHR1: 16174358 -16266950
Locus: 1p36.21-p36.13
Gene Diseases
The SPEN TNFRSF1B Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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