SPEN-PLEKHM2 Fusion FISH Probe
The SPEN-PLEKHM2 Fusion FISH Probe is used to confirm a fusion of the SPEN and PLEKHM2 genes. The fusion of the SPEN and PLEKHM2 genes has been associated with Sarcoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPEN-PLEKHM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-RERE | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-REOR | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-REGO | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-REGR | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-REAQ | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-ORRE | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-OROR | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-ORGO | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-GORE | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-GOOR | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-GOGO | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-GOGR | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-GRRE | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-GROR | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-GRGO | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-GRGR | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-AQRE | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-AQOR | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-AQGO | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-AQGR | 20 (40 μL) | 200 μL |
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| SPEN-PLEKHM2-20-AQAQ | 20 (40 μL) | 200 μL |
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SPEN Gene Summary
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
Gene Name: Spen Family Transcriptional Repressor
Chromosome: CHR1: 16174358 -16266950
Locus: 1p36.21-p36.13
PLEKHM2 Gene Summary
This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]
Gene Name: Pleckstrin Homology And RUN Domain Containing M2
Chromosome: CHR1: 16010826 -16061264
Locus: 1p36.21
Gene Diseases
The SPEN PLEKHM2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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