SPEN-FBLIM1 Fusion FISH Probe
The SPEN-FBLIM1 Fusion FISH Probe is used to confirm a fusion of the SPEN and FBLIM1 genes. The fusion of the SPEN and FBLIM1 genes has been associated with Liver Hepatocellular Carcinoma, Bladder Urothelial Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPEN-FBLIM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-RERE | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-REOR | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-REGO | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-REGR | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-REAQ | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-ORRE | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-OROR | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-ORGO | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-GORE | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-GOOR | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-GOGO | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-GOGR | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-GRRE | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-GROR | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-GRGO | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-GRGR | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-AQRE | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-AQOR | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-AQGO | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-AQGR | 20 (40 μL) | 200 μL |
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| SPEN-FBLIM1-20-AQAQ | 20 (40 μL) | 200 μL |
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SPEN Gene Summary
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
Gene Name: Spen Family Transcriptional Repressor
Chromosome: CHR1: 16174358 -16266950
Locus: 1p36.21-p36.13
FBLIM1 Gene Summary
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Filamin Binding LIM Protein 1
Chromosome: CHR1: 16085254 -16113084
Locus: 1p36.21
Gene Diseases
The SPEN FBLIM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Bladder Urothelial Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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