SPATA18-EXOC1 Fusion FISH Probe
The SPATA18-EXOC1 Fusion FISH Probe is used to confirm a fusion of the SPATA18 and EXOC1 genes. The fusion of the SPATA18 and EXOC1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPATA18-EXOC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-RERE | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-REOR | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-REGO | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-REGR | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-REAQ | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-ORRE | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-OROR | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-ORGO | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-GORE | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-GOOR | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-GOGO | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-GOGR | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-GRRE | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-GROR | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-GRGO | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-GRGR | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-AQRE | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-AQOR | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-AQGO | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-AQGR | 20 (40 μL) | 200 μL |
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| SPATA18-EXOC1-20-AQAQ | 20 (40 μL) | 200 μL |
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EXOC1 Gene Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Exocyst Complex Component 1
Chromosome: CHR4: 56719815 -56771244
Locus: 4q12
SPATA18 Gene Summary
This gene encodes a p53-inducible protein that is able to induce lysosome-like organelles within mitochondria that eliminate oxidized mitochondrial proteins, thereby contributing to mitochondrial quality control. Dysregulation of mitochondrial quality control is associated with cancer and degenerative diseases. The encoded protein mediates accumulation of the lysosome-like mitochondrial organelles through interaction with B cell lymphoma 2 interacting protein 3 and B cell lymphoma 2 interacting protein 3 like at the outer mitochondrial membrane, which allows translocation of lysosomal proteins to the mitochondrial matrix from the cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Gene Name: Spermatogenesis Associated 18
Chromosome: CHR4: 52917592 -52963458
Locus: 4q12
Gene Diseases
The SPATA18 EXOC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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