SPAG17-PCF11 Fusion FISH Probe
The SPAG17-PCF11 Fusion FISH Probe is used to confirm a fusion of the SPAG17 and PCF11 genes. The fusion of the SPAG17 and PCF11 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPAG17-PCF11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-RERE | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-REOR | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-REGO | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-REGR | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-REAQ | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-ORRE | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-OROR | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-ORGO | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-GORE | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-GOOR | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-GOGO | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-GOGR | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-GRRE | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-GROR | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-GRGO | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-GRGR | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-AQRE | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-AQOR | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-AQGO | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-AQGR | 20 (40 μL) | 200 μL |
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| SPAG17-PCF11-20-AQAQ | 20 (40 μL) | 200 μL |
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PCF11 Gene Summary
The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage. [provided by RefSeq, Oct 2016]
Gene Name: PCF11 Cleavage And Polyadenylation Factor Subunit
Chromosome: CHR11: 82868136 -82896835
Locus: 11q14.1
SPAG17 Gene Summary
This gene encodes a central pair protein present in the axonemes of cells with a "9 + 2" organization of microtubules. The encoded protein is required for the proper function of the axoneme. Mutations in the orthologous gene in mice lead to primary ciliary dyskinesia characterized by immotile nasal and tracheal cilia, reduced clearance of nasal mucus, profound respiratory distress, hydrocephalus, and neonatal lethality within twelve hours of birth due to impaired airway mucociliary clearance. Single-nucleotide polymorphisms in this gene are associated with human height and targeted mutations lead to skeletal malformations affecting the limbs in mice, suggesting a role for this gene in skeletal development. [provided by RefSeq, Feb 2017]
Gene Name: Sperm Associated Antigen 17
Chromosome: CHR1: 118496287 -118727848
Locus: 1p12
Gene Diseases
The SPAG17 PCF11 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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