SPAG1-STK3 Fusion FISH Probe
The SPAG1-STK3 Fusion FISH Probe is used to confirm a fusion of the SPAG1 and STK3 genes. The fusion of the SPAG1 and STK3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SPAG1-STK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-RERE | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-REOR | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-REGO | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-REGR | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-REAQ | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-ORRE | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-OROR | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-ORGO | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-GORE | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-GOOR | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-GOGO | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-GOGR | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-GRRE | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-GROR | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-GRGO | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-GRGR | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-AQRE | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-AQOR | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-AQGO | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-AQGR | 20 (40 μL) | 200 μL |
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| SPAG1-STK3-20-AQAQ | 20 (40 μL) | 200 μL |
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SPAG1 Gene Summary
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Sperm Associated Antigen 1
Chromosome: CHR8: 101170262 -101254132
Locus: 8q22.2
STK3 Gene Summary
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Serine/threonine Kinase 3
Chromosome: CHR8: 99466860 -99837909
Locus: 8q22.2
Gene Diseases
The SPAG1 STK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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