SP4-GPNMB Fusion FISH Probe
The SP4-GPNMB Fusion FISH Probe is used to confirm a fusion of the SP4 and GPNMB genes. The fusion of the SP4 and GPNMB genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SP4-GPNMB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SP4-GPNMB-20-AQAQ | 20 (40 μL) | 200 μL |
|
SP4 Gene Summary
The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016]
Gene Name: Sp4 Transcription Factor
Chromosome: CHR7: 21467688 -21554151
Locus: 7p15.3
GPNMB Gene Summary
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Glycoprotein Nmb
Chromosome: CHR7: 23286315 -23314729
Locus: 7p15.3
Gene Diseases
The SP4 GPNMB Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|