SP3-STK39 Fusion FISH Probe
The SP3-STK39 Fusion FISH Probe is used to confirm a fusion of the SP3 and STK39 genes. The fusion of the SP3 and STK39 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SP3-STK39-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-RERE | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-REOR | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-REGO | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-REGR | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-REAQ | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-ORRE | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-OROR | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-ORGO | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-ORAQ | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-GORE | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-GOOR | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-GOGO | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-GOGR | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-GOAQ | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-GRRE | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-GROR | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-GRGO | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-GRGR | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-GRAQ | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-AQRE | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-AQOR | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-AQGO | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-AQGR | 20 (40 μL) | 200 μL |
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| SP3-STK39-20-AQAQ | 20 (40 μL) | 200 μL |
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SP3 Gene Summary
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]
Gene Name: Sp3 Transcription Factor
Chromosome: CHR2: 174771186 -174830430
Locus: 2q31.1
STK39 Gene Summary
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
Gene Name: Serine/threonine Kinase 39
Chromosome: CHR2: 168810529 -169104105
Locus: 2q24.3
Gene Diseases
The SP3 STK39 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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