SP3-SLC8A1 Fusion FISH Probe
The SP3-SLC8A1 Fusion FISH Probe is used to confirm a fusion of the SP3 and SLC8A1 genes. The fusion of the SP3 and SLC8A1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SP3-SLC8A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-RERE | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-REOR | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-REGO | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-REGR | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-REAQ | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-ORRE | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-OROR | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-ORGO | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-GORE | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-GOOR | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-GOGO | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-GOGR | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-GRRE | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-GROR | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-GRGO | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-GRGR | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-AQRE | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-AQOR | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-AQGO | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-AQGR | 20 (40 μL) | 200 μL |
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| SP3-SLC8A1-20-AQAQ | 20 (40 μL) | 200 μL |
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SLC8A1 Gene Summary
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
Gene Name: Solute Carrier Family 8 Member A1
Chromosome: CHR2: 40339285 -40739575
Locus: 2p22.1
SP3 Gene Summary
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]
Gene Name: Sp3 Transcription Factor
Chromosome: CHR2: 174771186 -174830430
Locus: 2q31.1
Gene Diseases
The SP3 SLC8A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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