SP1-NPFF Fusion FISH Probe
The SP1-NPFF Fusion FISH Probe is used to confirm a fusion of the SP1 and NPFF genes. The fusion of the SP1 and NPFF genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SP1-NPFF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-RERE | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-REOR | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-REGO | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-REGR | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-REAQ | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-ORRE | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-OROR | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-ORGO | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-ORAQ | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-GORE | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-GOOR | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-GOGO | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-GOGR | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-GOAQ | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-GRRE | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-GROR | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-GRGO | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-GRGR | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-GRAQ | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-AQRE | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-AQOR | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-AQGO | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-AQGR | 20 (40 μL) | 200 μL |
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| SP1-NPFF-20-AQAQ | 20 (40 μL) | 200 μL |
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SP1 Gene Summary
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Gene Name: Sp1 Transcription Factor
Chromosome: CHR12: 53773978 -53810226
Locus: 12q13.13
NPFF Gene Summary
This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Neuropeptide FF-amide Peptide Precursor
Chromosome: CHR12: 53900473 -53901422
Locus: 12q13.13
Gene Diseases
The SP1 NPFF Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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