SOX6-PTPRJ Fusion FISH Probe
The SOX6-PTPRJ Fusion FISH Probe is used to confirm a fusion of the SOX6 and PTPRJ genes. The fusion of the SOX6 and PTPRJ genes has been associated with Brain Lower Grade Glioma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SOX6-PTPRJ-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-RERE | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-REOR | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-REGO | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-REGR | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-REAQ | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-ORRE | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-OROR | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-ORGO | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-ORAQ | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-GORE | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-GOOR | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-GOGO | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-GOGR | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-GOAQ | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-GRRE | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-GROR | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-GRGO | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-GRGR | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-GRAQ | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-AQRE | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-AQOR | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-AQGO | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-AQGR | 20 (40 μL) | 200 μL |
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| SOX6-PTPRJ-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRJ Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type J
Chromosome: CHR11: 48002109 -48192394
Locus: 11p11.2
SOX6 Gene Summary
This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Gene Name: SRY-box 6
Chromosome: CHR11: 15987994 -16497935
Locus: 11p15.2
Gene Diseases
The SOX6 PTPRJ Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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