SOS2-NRXN3 Fusion FISH Probe
The SOS2-NRXN3 Fusion FISH Probe is used to confirm a fusion of the SOS2 and NRXN3 genes. The fusion of the SOS2 and NRXN3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SOS2-NRXN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-RERE | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-REOR | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-REGO | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-REGR | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-REAQ | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-ORRE | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-OROR | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-ORGO | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-GORE | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-GOOR | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-GOGO | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-GOGR | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-GRRE | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-GROR | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-GRGO | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-GRGR | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-AQRE | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-AQOR | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-AQGO | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-AQGR | 20 (40 μL) | 200 μL |
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| SOS2-NRXN3-20-AQAQ | 20 (40 μL) | 200 μL |
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SOS2 Gene Summary
This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016]
Gene Name: SOS Ras/Rho Guanine Nucleotide Exchange Factor 2
Chromosome: CHR14: 50583845 -50698099
Locus: 14q21.3
NRXN3 Gene Summary
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
Gene Name: Neurexin 3
Chromosome: CHR14: 78870092 -80330760
Locus: 14q24.3-q31.1
Gene Diseases
The SOS2 NRXN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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