SORL1-DDX6 Fusion FISH Probe
The SORL1-DDX6 Fusion FISH Probe is used to confirm a fusion of the SORL1 and DDX6 genes. The fusion of the SORL1 and DDX6 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SORL1-DDX6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-RERE | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-REOR | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-REGO | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-REGR | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-REAQ | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-ORRE | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-OROR | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-ORGO | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-ORAQ | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-GORE | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-GOOR | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-GOGO | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-GOGR | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-GOAQ | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-GRRE | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-GROR | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-GRGO | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-GRGR | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-GRAQ | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-AQRE | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-AQOR | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-AQGO | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-AQGR | 20 (40 μL) | 200 μL |
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| SORL1-DDX6-20-AQAQ | 20 (40 μL) | 200 μL |
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DDX6 Gene Summary
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]
Gene Name: DEAD-box Helicase 6
Chromosome: CHR11: 118618472 -118661972
Locus: 11q23.3
SORL1 Gene Summary
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]
Gene Name: Sortilin Related Receptor 1
Chromosome: CHR11: 121322911 -121504471
Locus: 11q24.1
Gene Diseases
The SORL1 DDX6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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