SORD-TRIM69 Fusion FISH Probe
The SORD-TRIM69 Fusion FISH Probe is used to confirm a fusion of the SORD and TRIM69 genes. The fusion of the SORD and TRIM69 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SORD-TRIM69-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-RERE | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-REOR | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-REGO | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-REGR | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-REAQ | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-ORRE | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-OROR | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-ORGO | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-ORAQ | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-GORE | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-GOOR | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-GOGO | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-GOGR | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-GOAQ | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-GRRE | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-GROR | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-GRGO | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-GRGR | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-GRAQ | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-AQRE | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-AQOR | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-AQGO | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-AQGR | 20 (40 μL) | 200 μL |
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| SORD-TRIM69-20-AQAQ | 20 (40 μL) | 200 μL |
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SORD Gene Summary
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
Gene Name: Sorbitol Dehydrogenase
Chromosome: CHR15: 45315301 -45367287
Locus: 15q21.1
TRIM69 Gene Summary
This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Tripartite Motif Containing 69
Chromosome: CHR15: 45028559 -45060025
Locus: 15q21.1
Gene Diseases
The SORD TRIM69 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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