SORBS2-MRPS35 Fusion FISH Probe
The SORBS2-MRPS35 Fusion FISH Probe is used to confirm a fusion of the SORBS2 and MRPS35 genes. The fusion of the SORBS2 and MRPS35 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SORBS2-MRPS35-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-RERE | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-REOR | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-REGO | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-REGR | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-REAQ | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-ORRE | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-OROR | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-ORGO | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-ORAQ | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-GORE | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-GOOR | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-GOGO | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-GOGR | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-GOAQ | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-GRRE | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-GROR | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-GRGO | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-GRGR | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-GRAQ | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-AQRE | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-AQOR | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-AQGO | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-AQGR | 20 (40 μL) | 200 μL |
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| SORBS2-MRPS35-20-AQAQ | 20 (40 μL) | 200 μL |
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SORBS2 Gene Summary
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Sorbin And SH3 Domain Containing 2
Chromosome: CHR4: 186506597 -186877870
Locus: 4q35.1
MRPS35 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
Gene Name: Mitochondrial Ribosomal Protein S35
Chromosome: CHR12: 27863705 -27909237
Locus: 12p11.22
Gene Diseases
The SORBS2 MRPS35 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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