SOCS6-PMS1 Fusion FISH Probe
The SOCS6-PMS1 Fusion FISH Probe is used to confirm a fusion of the SOCS6 and PMS1 genes. The fusion of the SOCS6 and PMS1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SOCS6-PMS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-RERE | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-REOR | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-REGO | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-REGR | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-REAQ | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-ORRE | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-OROR | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-ORGO | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-GORE | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-GOOR | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-GOGO | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-GOGR | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-GRRE | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-GROR | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-GRGO | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-GRGR | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-AQRE | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-AQOR | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-AQGO | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-AQGR | 20 (40 μL) | 200 μL |
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| SOCS6-PMS1-20-AQAQ | 20 (40 μL) | 200 μL |
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PMS1 Gene Summary
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]
Gene Name: PMS1 Homolog 1, Mismatch Repair System Component
Chromosome: CHR2: 190648810 -190742355
Locus: 2q32.2
SOCS6 Gene Summary
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Gene Name: Suppressor Of Cytokine Signaling 6
Chromosome: CHR18: 67956136 -67997434
Locus: 18q22.2
Gene Diseases
The SOCS6 PMS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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