SOCS5-SLC8A1 Fusion FISH Probe
The SOCS5-SLC8A1 Fusion FISH Probe is used to confirm a fusion of the SOCS5 and SLC8A1 genes. The fusion of the SOCS5 and SLC8A1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SOCS5-SLC8A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-RERE | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-REOR | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-REGO | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-REGR | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-REAQ | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-ORRE | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-OROR | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-ORGO | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-GORE | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-GOOR | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-GOGO | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-GOGR | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-GRRE | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-GROR | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-GRGO | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-GRGR | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-AQRE | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-AQOR | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-AQGO | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-AQGR | 20 (40 μL) | 200 μL |
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| SOCS5-SLC8A1-20-AQAQ | 20 (40 μL) | 200 μL |
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SLC8A1 Gene Summary
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
Gene Name: Solute Carrier Family 8 Member A1
Chromosome: CHR2: 40339285 -40739575
Locus: 2p22.1
SOCS5 Gene Summary
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Suppressor Of Cytokine Signaling 5
Chromosome: CHR2: 46926098 -46989927
Locus: 2p21
Gene Diseases
The SOCS5 SLC8A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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