SNX8-KDELR2 Fusion FISH Probe
The SNX8-KDELR2 Fusion FISH Probe is used to confirm a fusion of the SNX8 and KDELR2 genes. The fusion of the SNX8 and KDELR2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SNX8-KDELR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-RERE | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-REOR | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-REGO | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-REGR | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-REAQ | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-ORRE | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-OROR | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-ORGO | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-GORE | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-GOOR | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-GOGO | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-GOGR | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-GRRE | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-GROR | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-GRGO | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-GRGR | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-AQRE | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-AQOR | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-AQGO | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-AQGR | 20 (40 μL) | 200 μL |
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| SNX8-KDELR2-20-AQAQ | 20 (40 μL) | 200 μL |
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KDELR2 Gene Summary
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: KDEL Endoplasmic Reticulum Protein Retention Receptor 2
Chromosome: CHR7: 6500711 -6523849
Locus: 7p22.1
SNX8 Gene Summary
The Sorting Nexin 8 (SNX8) gene is located on chr7 :2291404-2354099 at 7p22.3.
Gene Name: Sorting Nexin 8
Chromosome: CHR7: 2291404 -2354099
Locus: 7p22.3
Gene Diseases
The SNX8 KDELR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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