SNX5-PCSK2 Fusion FISH Probe
The SNX5-PCSK2 Fusion FISH Probe is used to confirm a fusion of the SNX5 and PCSK2 genes. The fusion of the SNX5 and PCSK2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SNX5-PCSK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-RERE | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-REOR | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-REGO | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-REGR | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-REAQ | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-ORRE | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-OROR | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-ORGO | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-GORE | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-GOOR | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-GOGO | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-GOGR | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-GRRE | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-GROR | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-GRGO | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-GRGR | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-AQRE | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-AQOR | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-AQGO | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-AQGR | 20 (40 μL) | 200 μL |
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| SNX5-PCSK2-20-AQAQ | 20 (40 μL) | 200 μL |
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PCSK2 Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]
Gene Name: Proprotein Convertase Subtilisin/kexin Type 2
Chromosome: CHR20: 17206751 -17465222
Locus: 20p12.1
SNX5 Gene Summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Gene Name: Sorting Nexin 5
Chromosome: CHR20: 17922243 -17949490
Locus: 20p11.23
Gene Diseases
The SNX5 PCSK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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