SNRPN-CYFIP1 Fusion FISH Probe
The SNRPN-CYFIP1 Fusion FISH Probe is used to confirm a fusion of the SNRPN and CYFIP1 genes. The fusion of the SNRPN and CYFIP1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SNRPN-CYFIP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-RERE | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-REOR | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-REGO | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-REGR | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-REAQ | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-ORRE | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-OROR | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-ORGO | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-GORE | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-GOOR | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-GOGO | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-GOGR | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-GRRE | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-GROR | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-GRGO | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-GRGR | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-AQRE | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-AQOR | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-AQGO | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-AQGR | 20 (40 μL) | 200 μL |
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| SNRPN-CYFIP1-20-AQAQ | 20 (40 μL) | 200 μL |
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SNRPN Gene Summary
This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017]
Gene Name: Small Nuclear Ribonucleoprotein Polypeptide N
Chromosome: CHR15: 25068793 -25223729
Locus: 15q11.2
CYFIP1 Gene Summary
This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017]
Gene Name: Cytoplasmic FMR1 Interacting Protein 1
Chromosome: CHR15: 22892683 -23003603
Locus: 15q11.2
Gene Diseases
The SNRPN CYFIP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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