SMURF1-TRIM4 Fusion FISH Probe
The SMURF1-TRIM4 Fusion FISH Probe is used to confirm a fusion of the SMURF1 and TRIM4 genes. The fusion of the SMURF1 and TRIM4 genes has been associated with Brain Lower Grade Glioma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMURF1-TRIM4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-RERE | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-REOR | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-REGO | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-REGR | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-REAQ | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-ORRE | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-OROR | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-ORGO | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-GORE | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-GOOR | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-GOGO | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-GOGR | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-GRRE | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-GROR | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-GRGO | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-GRGR | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-AQRE | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-AQOR | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-AQGO | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-AQGR | 20 (40 μL) | 200 μL |
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| SMURF1-TRIM4-20-AQAQ | 20 (40 μL) | 200 μL |
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SMURF1 Gene Summary
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
Gene Name: SMAD Specific E3 Ubiquitin Protein Ligase 1
Chromosome: CHR7: 98625057 -98741743
Locus: 7q22.1
TRIM4 Gene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010]
Gene Name: Tripartite Motif Containing 4
Chromosome: CHR7: 99488029 -99517223
Locus: 7q22.1
Gene Diseases
The SMURF1 TRIM4 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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