SMURF1-SLC26A5 Fusion FISH Probe
The SMURF1-SLC26A5 Fusion FISH Probe is used to confirm a fusion of the SMURF1 and SLC26A5 genes. The fusion of the SMURF1 and SLC26A5 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMURF1-SLC26A5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-RERE | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-REOR | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-REGO | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-REGR | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-REAQ | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-ORRE | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-OROR | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-ORGO | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-GORE | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-GOOR | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-GOGO | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-GOGR | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-GRRE | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-GROR | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-GRGO | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-GRGR | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-AQRE | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-AQOR | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-AQGO | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-AQGR | 20 (40 μL) | 200 μL |
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| SMURF1-SLC26A5-20-AQAQ | 20 (40 μL) | 200 μL |
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SMURF1 Gene Summary
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
Gene Name: SMAD Specific E3 Ubiquitin Protein Ligase 1
Chromosome: CHR7: 98625057 -98741743
Locus: 7q22.1
SLC26A5 Gene Summary
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Gene Name: Solute Carrier Family 26 Member 5
Chromosome: CHR7: 102993176 -103086624
Locus: 7q22.1
Gene Diseases
The SMURF1 SLC26A5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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