SMURF1-KPNA7 Fusion FISH Probe
The SMURF1-KPNA7 Fusion FISH Probe is used to confirm a fusion of the SMURF1 and KPNA7 genes. The fusion of the SMURF1 and KPNA7 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMURF1-KPNA7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-RERE | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-REOR | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-REGO | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-REGR | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-REAQ | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-ORRE | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-OROR | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-ORGO | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-GORE | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-GOOR | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-GOGO | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-GOGR | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-GRRE | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-GROR | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-GRGO | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-GRGR | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-AQRE | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-AQOR | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-AQGO | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-AQGR | 20 (40 μL) | 200 μL |
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| SMURF1-KPNA7-20-AQAQ | 20 (40 μL) | 200 μL |
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SMURF1 Gene Summary
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
Gene Name: SMAD Specific E3 Ubiquitin Protein Ligase 1
Chromosome: CHR7: 98625057 -98741743
Locus: 7q22.1
KPNA7 Gene Summary
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Jul 2016]
Gene Name: Karyopherin Subunit Alpha 7
Chromosome: CHR7: 98771196 -98805089
Locus: 7q22.1
Gene Diseases
The SMURF1 KPNA7 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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