SMURF1-CFLAR Fusion FISH Probe
The SMURF1-CFLAR Fusion FISH Probe is used to confirm a fusion of the SMURF1 and CFLAR genes. The fusion of the SMURF1 and CFLAR genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMURF1-CFLAR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-RERE | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-REOR | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-REGO | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-REGR | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-REAQ | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-ORRE | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-OROR | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-ORGO | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-GORE | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-GOOR | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-GOGO | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-GOGR | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-GRRE | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-GROR | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-GRGO | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-GRGR | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-AQRE | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-AQOR | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-AQGO | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-AQGR | 20 (40 μL) | 200 μL |
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| SMURF1-CFLAR-20-AQAQ | 20 (40 μL) | 200 μL |
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CFLAR Gene Summary
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Gene Name: CASP8 And FADD Like Apoptosis Regulator
Chromosome: CHR2: 201980876 -202037411
Locus: 2q33.1
SMURF1 Gene Summary
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
Gene Name: SMAD Specific E3 Ubiquitin Protein Ligase 1
Chromosome: CHR7: 98625057 -98741743
Locus: 7q22.1
Gene Diseases
The SMURF1 CFLAR Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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