SMU1-B4GALT1 Fusion FISH Probe
The SMU1-B4GALT1 Fusion FISH Probe is used to confirm a fusion of the SMU1 and B4GALT1 genes. The fusion of the SMU1 and B4GALT1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMU1-B4GALT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-RERE | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-REOR | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-REGO | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-REGR | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-REAQ | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-ORRE | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-OROR | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-ORGO | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-GORE | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-GOOR | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-GOGO | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-GOGR | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-GRRE | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-GROR | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-GRGO | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-GRGR | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-AQRE | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-AQOR | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-AQGO | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-AQGR | 20 (40 μL) | 200 μL |
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| SMU1-B4GALT1-20-AQAQ | 20 (40 μL) | 200 μL |
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B4GALT1 Gene Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]
Gene Name: Beta-1,4-galactosyltransferase 1
Chromosome: CHR9: 33110638 -33167356
Locus: 9p21.1
SMU1 Gene Summary
The SMU1, DNA Replication Regulator And Spliceosomal Factor (SMU1) gene is located on chr9 :33041849-33076714 at 9p21.1.
Gene Name: SMU1, DNA Replication Regulator And Spliceosomal Factor
Chromosome: CHR9: 33041849 -33076714
Locus: 9p21.1
Gene Diseases
The SMU1 B4GALT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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