SMOX-PANK2 Fusion FISH Probe
The SMOX-PANK2 Fusion FISH Probe is used to confirm a fusion of the SMOX and PANK2 genes. The fusion of the SMOX and PANK2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMOX-PANK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-RERE | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-REOR | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-REGO | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-REGR | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-REAQ | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-ORRE | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-OROR | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-ORGO | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-GORE | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-GOOR | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-GOGO | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-GOGR | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-GRRE | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-GROR | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-GRGO | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-GRGR | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-AQRE | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-AQOR | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-AQGO | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-AQGR | 20 (40 μL) | 200 μL |
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| SMOX-PANK2-20-AQAQ | 20 (40 μL) | 200 μL |
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SMOX Gene Summary
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]
Gene Name: Spermine Oxidase
Chromosome: CHR20: 4129449 -4168369
Locus: 20p13
PANK2 Gene Summary
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Pantothenate Kinase 2
Chromosome: CHR20: 3869485 -3904502
Locus: 20p13
Gene Diseases
The SMOX PANK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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