SMOX-EIF3D Fusion FISH Probe
The SMOX-EIF3D Fusion FISH Probe is used to confirm a fusion of the SMOX and EIF3D genes. The fusion of the SMOX and EIF3D genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMOX-EIF3D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-RERE | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-REOR | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-REGO | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-REGR | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-REAQ | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-ORRE | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-OROR | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-ORGO | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-GORE | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-GOOR | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-GOGO | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-GOGR | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-GRRE | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-GROR | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-GRGO | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-GRGR | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-AQRE | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-AQOR | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-AQGO | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-AQGR | 20 (40 μL) | 200 μL |
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| SMOX-EIF3D-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF3D Gene Summary
Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]
Gene Name: Eukaryotic Translation Initiation Factor 3 Subunit D
Chromosome: CHR22: 36906896 -36925277
Locus: 22q12.3
SMOX Gene Summary
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]
Gene Name: Spermine Oxidase
Chromosome: CHR20: 4129449 -4168369
Locus: 20p13
Gene Diseases
The SMOX EIF3D Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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