SMG6-SHPK Fusion FISH Probe
The SMG6-SHPK Fusion FISH Probe is used to confirm a fusion of the SMG6 and SHPK genes. The fusion of the SMG6 and SHPK genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMG6-SHPK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-RERE | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-REOR | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-REGO | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-REGR | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-REAQ | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-ORRE | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-OROR | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-ORGO | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-GORE | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-GOOR | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-GOGO | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-GOGR | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-GRRE | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-GROR | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-GRGO | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-GRGR | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-AQRE | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-AQOR | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-AQGO | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-AQGR | 20 (40 μL) | 200 μL |
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| SMG6-SHPK-20-AQAQ | 20 (40 μL) | 200 μL |
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SMG6 Gene Summary
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]
Gene Name: SMG6, Nonsense Mediated MRNA Decay Factor
Chromosome: CHR17: 1963132 -2207069
Locus: 17p13.3
SHPK Gene Summary
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]
Gene Name: Sedoheptulokinase
Chromosome: CHR17: 3511555 -3539616
Locus: 17p13.2
Gene Diseases
The SMG6 SHPK Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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