SMG6-RECK Fusion FISH Probe
The SMG6-RECK Fusion FISH Probe is used to confirm a fusion of the SMG6 and RECK genes. The fusion of the SMG6 and RECK genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMG6-RECK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-RERE | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-REOR | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-REGO | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-REGR | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-REAQ | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-ORRE | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-OROR | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-ORGO | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-GORE | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-GOOR | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-GOGO | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-GOGR | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-GRRE | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-GROR | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-GRGO | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-GRGR | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-AQRE | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-AQOR | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-AQGO | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-AQGR | 20 (40 μL) | 200 μL |
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| SMG6-RECK-20-AQAQ | 20 (40 μL) | 200 μL |
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RECK Gene Summary
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Reversion Inducing Cysteine Rich Protein With Kazal Motifs
Chromosome: CHR9: 36036909 -36124452
Locus: 9p13.3
SMG6 Gene Summary
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]
Gene Name: SMG6, Nonsense Mediated MRNA Decay Factor
Chromosome: CHR17: 1963132 -2207069
Locus: 17p13.3
Gene Diseases
The SMG6 RECK Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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