SMG6-NXN Fusion FISH Probe
The SMG6-NXN Fusion FISH Probe is used to confirm a fusion of the SMG6 and NXN genes. The fusion of the SMG6 and NXN genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMG6-NXN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-RERE | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-REOR | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-REGO | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-REGR | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-REAQ | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-ORRE | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-OROR | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-ORGO | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-GORE | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-GOOR | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-GOGO | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-GOGR | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-GRRE | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-GROR | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-GRGO | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-GRGR | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-AQRE | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-AQOR | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-AQGO | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-AQGR | 20 (40 μL) | 200 μL |
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| SMG6-NXN-20-AQAQ | 20 (40 μL) | 200 μL |
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SMG6 Gene Summary
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]
Gene Name: SMG6, Nonsense Mediated MRNA Decay Factor
Chromosome: CHR17: 1963132 -2207069
Locus: 17p13.3
NXN Gene Summary
This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]
Gene Name: Nucleoredoxin
Chromosome: CHR17: 702552 -882998
Locus: 17p13.3
Gene Diseases
The SMG6 NXN Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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