SMG6-DHX33 Fusion FISH Probe
The SMG6-DHX33 Fusion FISH Probe is used to confirm a fusion of the SMG6 and DHX33 genes. The fusion of the SMG6 and DHX33 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMG6-DHX33-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-RERE | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-REOR | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-REGO | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-REGR | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-REAQ | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-ORRE | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-OROR | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-ORGO | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-GORE | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-GOOR | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-GOGO | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-GOGR | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-GRRE | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-GROR | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-GRGO | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-GRGR | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-AQRE | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-AQOR | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-AQGO | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-AQGR | 20 (40 μL) | 200 μL |
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| SMG6-DHX33-20-AQAQ | 20 (40 μL) | 200 μL |
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SMG6 Gene Summary
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]
Gene Name: SMG6, Nonsense Mediated MRNA Decay Factor
Chromosome: CHR17: 1963132 -2207069
Locus: 17p13.3
DHX33 Gene Summary
This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Name: DEAH-box Helicase 33
Chromosome: CHR17: 5344231 -5372380
Locus: 17p13.2
Gene Diseases
The SMG6 DHX33 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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