SMC3-MXI1 Fusion FISH Probe
The SMC3-MXI1 Fusion FISH Probe is used to confirm a fusion of the SMC3 and MXI1 genes. The fusion of the SMC3 and MXI1 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMC3-MXI1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-RERE | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-REOR | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-REGO | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-REGR | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-REAQ | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-ORRE | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-OROR | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-ORGO | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-GORE | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-GOOR | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-GOGO | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-GOGR | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-GRRE | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-GROR | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-GRGO | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-GRGR | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-AQRE | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-AQOR | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-AQGO | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-AQGR | 20 (40 μL) | 200 μL |
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| SMC3-MXI1-20-AQAQ | 20 (40 μL) | 200 μL |
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MXI1 Gene Summary
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Gene Name: MAX Interactor 1, Dimerization Protein
Chromosome: CHR10: 111967362 -112047123
Locus: 10q25.2
SMC3 Gene Summary
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]
Gene Name: Structural Maintenance Of Chromosomes 3
Chromosome: CHR10: 112327448 -112364392
Locus: 10q25.2
Gene Diseases
The SMC3 MXI1 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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