SMARCE1-RARA Fusion FISH Probe
The SMARCE1-RARA Fusion FISH Probe is used to confirm a fusion of the SMARCE1 and RARA genes. The fusion of the SMARCE1 and RARA genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMARCE1-RARA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-RERE | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-REOR | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-REGO | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-REGR | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-REAQ | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-ORRE | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-OROR | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-ORGO | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-GORE | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-GOOR | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-GOGO | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-GOGR | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-GRRE | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-GROR | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-GRGO | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-GRGR | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-AQRE | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-AQOR | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-AQGO | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-AQGR | 20 (40 μL) | 200 μL |
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| SMARCE1-RARA-20-AQAQ | 20 (40 μL) | 200 μL |
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RARA Gene Summary
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Gene Name: Retinoic Acid Receptor Alpha
Chromosome: CHR17: 38465422 -38513895
Locus: 17q21.2
SMARCE1 Gene Summary
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1
Chromosome: CHR17: 38783975 -38804103
Locus: 17q21.2
Gene Diseases
The SMARCE1 RARA Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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