SMARCC1-DHX30 Fusion FISH Probe
The SMARCC1-DHX30 Fusion FISH Probe is used to confirm a fusion of the SMARCC1 and DHX30 genes. The fusion of the SMARCC1 and DHX30 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMARCC1-DHX30-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-RERE | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-REOR | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-REGO | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-REGR | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-REAQ | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-ORRE | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-OROR | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-ORGO | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-GORE | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-GOOR | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-GOGO | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-GOGR | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-GRRE | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-GROR | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-GRGO | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-GRGR | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-AQRE | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-AQOR | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-AQGO | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-AQGR | 20 (40 μL) | 200 μL |
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| SMARCC1-DHX30-20-AQAQ | 20 (40 μL) | 200 μL |
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SMARCC1 Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin Subfamily C Member 1
Chromosome: CHR3: 47627377 -47823405
Locus: 3p21.31
DHX30 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The family member encoded by this gene is a mitochondrial nucleoid protein that associates with mitochondrial DNA. It has also been identified as a component of a transcriptional repressor complex that functions in retinal development, and it is required to optimize the function of the zinc-finger antiviral protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Name: DExH-box Helicase 30
Chromosome: CHR3: 47844398 -47891686
Locus: 3p21.31
Gene Diseases
The SMARCC1 DHX30 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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