SMARCC1-CDC25A Fusion FISH Probe
The SMARCC1-CDC25A Fusion FISH Probe is used to confirm a fusion of the SMARCC1 and CDC25A genes. The fusion of the SMARCC1 and CDC25A genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMARCC1-CDC25A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-RERE | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-REOR | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-REGO | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-REGR | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-REAQ | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-ORRE | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-OROR | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-ORGO | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-GORE | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-GOOR | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-GOGO | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-GOGR | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-GRRE | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-GROR | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-GRGO | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-GRGR | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-AQRE | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-AQOR | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-AQGO | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-AQGR | 20 (40 μL) | 200 μL |
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| SMARCC1-CDC25A-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC25A Gene Summary
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Cell Division Cycle 25A
Chromosome: CHR3: 48198667 -48229801
Locus: 3p21.31
SMARCC1 Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin Subfamily C Member 1
Chromosome: CHR3: 47627377 -47823405
Locus: 3p21.31
Gene Diseases
The SMARCC1 CDC25A Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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