SMARCB1-SNW1 Fusion FISH Probe
The SMARCB1-SNW1 Fusion FISH Probe is used to confirm a fusion of the SMARCB1 and SNW1 genes. The fusion of the SMARCB1 and SNW1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMARCB1-SNW1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-RERE | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-REOR | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-REGO | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-REGR | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-REAQ | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-ORRE | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-OROR | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-ORGO | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-GORE | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-GOOR | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-GOGO | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-GOGR | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-GRRE | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-GROR | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-GRGO | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-GRGR | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-AQRE | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-AQOR | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-AQGO | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-AQGR | 20 (40 μL) | 200 μL |
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| SMARCB1-SNW1-20-AQAQ | 20 (40 μL) | 200 μL |
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SMARCB1 Gene Summary
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1
Chromosome: CHR22: 24129149 -24176705
Locus: 22q11
SNW1 Gene Summary
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: SNW Domain Containing 1
Chromosome: CHR14: 78183943 -78227497
Locus: 14q24.3
Gene Diseases
The SMARCB1 SNW1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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