SMARCAD1-GRID2 Fusion FISH Probe
The SMARCAD1-GRID2 Fusion FISH Probe is used to confirm a fusion of the SMARCAD1 and GRID2 genes. The fusion of the SMARCAD1 and GRID2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SMARCAD1-GRID2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SMARCAD1-GRID2-20-AQAQ | 20 (40 μL) | 200 μL |
|
GRID2 Gene Summary
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]
Gene Name: Glutamate Ionotropic Receptor Delta Type Subunit 2
Chromosome: CHR4: 93225549 -94693649
Locus: 4q22.1-q22.2
SMARCAD1 Gene Summary
This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: SWI/SNF-related, Matrix-associated Actin-dependent Regulator Of Chromatin, Subfamily A, Containing DEAD/H Box 1
Chromosome: CHR4: 95128758 -95212443
Locus: 4q22.3
Gene Diseases
The SMARCAD1 GRID2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|