SMARCA4-RNF216 Fusion FISH Probe
The SMARCA4-RNF216 Fusion FISH Probe is used to confirm a fusion of the SMARCA4 and RNF216 genes. The fusion of the SMARCA4 and RNF216 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMARCA4-RNF216-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-RERE | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-REOR | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-REGO | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-REGR | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-REAQ | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-ORRE | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-OROR | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-ORGO | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-GORE | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-GOOR | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-GOGO | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-GOGR | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-GRRE | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-GROR | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-GRGO | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-GRGR | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-AQRE | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-AQOR | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-AQGO | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-AQGR | 20 (40 μL) | 200 μL |
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| SMARCA4-RNF216-20-AQAQ | 20 (40 μL) | 200 μL |
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SMARCA4 Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4
Chromosome: CHR19: 11071597 -11172958
Locus: 19p13.2
RNF216 Gene Summary
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
Gene Name: Ring Finger Protein 216
Chromosome: CHR7: 5659671 -5821361
Locus: 7p22.1
Gene Diseases
The SMARCA4 RNF216 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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