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SMARCA4-DOCK6 Fusion FISH Probe

The SMARCA4-DOCK6 Fusion FISH Probe is used to confirm a fusion of the SMARCA4 and DOCK6 genes. The fusion of the SMARCA4 and DOCK6 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
SMARCA4-DOCK6-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-RERE 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-REOR 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-REGO 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-REGR 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-REAQ 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-ORRE 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-OROR 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-ORGO 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-ORAQ 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-GORE 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-GOOR 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-GOGO 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-GOGR 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-GOAQ 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-GRRE 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-GROR 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-GRGO 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-GRGR 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-GRAQ 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-AQRE 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-AQOR 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-AQGO 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-AQGR 20 (40 μL) 200 μL
SMARCA4-DOCK6-20-AQAQ 20 (40 μL) 200 μL

SMARCA4 Gene Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4

Chromosome: CHR19: 11071597 -11172958

Locus: 19p13.2

DOCK6 Gene Summary

This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]

Gene Name: Dedicator Of Cytokinesis 6

Chromosome: CHR19: 11309970 -11373157

Locus: 19p13.2

Gene Diseases

The SMARCA4 DOCK6 Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.