SMARCA4-DOCK6 Fusion FISH Probe
The SMARCA4-DOCK6 Fusion FISH Probe is used to confirm a fusion of the SMARCA4 and DOCK6 genes. The fusion of the SMARCA4 and DOCK6 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMARCA4-DOCK6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-RERE | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-REOR | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-REGO | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-REGR | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-REAQ | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-ORRE | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-OROR | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-ORGO | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-GORE | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-GOOR | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-GOGO | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-GOGR | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-GRRE | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-GROR | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-GRGO | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-GRGR | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-AQRE | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-AQOR | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-AQGO | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-AQGR | 20 (40 μL) | 200 μL |
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| SMARCA4-DOCK6-20-AQAQ | 20 (40 μL) | 200 μL |
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SMARCA4 Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4
Chromosome: CHR19: 11071597 -11172958
Locus: 19p13.2
DOCK6 Gene Summary
This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
Gene Name: Dedicator Of Cytokinesis 6
Chromosome: CHR19: 11309970 -11373157
Locus: 19p13.2
Gene Diseases
The SMARCA4 DOCK6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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