SMARCA2-DMRT1 Fusion FISH Probe
The SMARCA2-DMRT1 Fusion FISH Probe is used to confirm a fusion of the SMARCA2 and DMRT1 genes. The fusion of the SMARCA2 and DMRT1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMARCA2-DMRT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-RERE | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-REOR | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-REGO | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-REGR | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-REAQ | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-ORRE | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-OROR | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-ORGO | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-GORE | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-GOOR | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-GOGO | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-GOGR | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-GRRE | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-GROR | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-GRGO | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-GRGR | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-AQRE | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-AQOR | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-AQGO | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-AQGR | 20 (40 μL) | 200 μL |
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| SMARCA2-DMRT1-20-AQAQ | 20 (40 μL) | 200 μL |
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DMRT1 Gene Summary
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]
Gene Name: Doublesex And Mab-3 Related Transcription Factor 1
Chromosome: CHR9: 841689 -969090
Locus: 9p24.3
SMARCA2 Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2
Chromosome: CHR9: 2015341 -2193623
Locus: 9p24.3
Gene Diseases
The SMARCA2 DMRT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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